On the other hand, the expression of miRNA-145 has been associated with key metabolic parameters in obesity and glucose metabolism, such as visceral fat area, HbA1c, plasma glucose, and circulating levels of leptin, adiponectin, and interleukin- 6 [99], as well as the risk of development cardiovascular disease (CVD). The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.