It has been suggested that tumor suppression by miRNA-145 is associated with the inhibition or stimulation of tumor angiogenesis; potential mechanisms of action are associated with the regulation of the insulin receptor substrate 1 (IRS1) gene, which suppresses N-RAS and VEGF-A (RAS mediates vascular endothelial growth factor), inhibiting tumor angiogenesis [32,95]. This evidence concerns the gene IRS1 and neoplasm.