To assess whether the Nrf2 reporter line could be exploited for the detection of Nrf2 pathway modulation by additional small molecules, we provided the transgenic fish with the known radical scavenger Edaravone (MCI-186), which has been already shown to dampen the progression of amyotrophic lateral sclerosis (ALS) and exert antioxidant effects in asthma and cerebral infarction through the Nrf2 pathway [18,19]. The gene discussed is NFE2L2; the disease is amyotrophic lateral sclerosis.