The variables that were independently associated with ILD were moderate-high disease activity according to the DAS28-ESR (β = 0.914; p = 0.017) and high levels of ACPA (β = 1.064; p = 0.014), IL-18 in pg/mL (β = 0.091; p = 0.044), MCP-1/CCL2 in pg/mL (β = 0.031; p = 0.049), and SDF-1 alpha in pg/mL (β = 0.081; p = 0.010). This evidence concerns the gene CCL2 and interstitial lung disease.