Bartels et al. reported that microglia in the classical activation state—known as M1 microglia—are significantly active in the SN of PD-like mice, secreting inflammatory factors such as tumor necrosis factor-alpha (TNF-α), and interleukin-1 beta (IL-1β), thus leading to the degeneration of dopaminergic neurons [4]. This evidence concerns the gene IL1B and Parkinson disease.