Research has demonstrated an association between QEEG parameters and AD risk variants in the APOE, CLU, PICALM, IL1RAP, UNC5C, and NAV2 genes in AD [38,39,40,41,42] and MCI patients [43,44,45] as well as in healthy adults [46,47,48,49,50]. The gene discussed is PICALM; the disease is Alzheimer disease.