In humans, AMACO was also referred to as colon cancer secreted protein-2 (CCSP-2), as it was found to be upregulated in colon cancer [8], and epigenetic and transcriptional dysregulation of VWA2 was found to be associated with an MYC-driven oncogenic program in colorectal cancer [9]. Here, VWA2 is linked to malignant colon neoplasm.