However, the stratification of the patients based on cardiovascular involvement showed a few statistically significant differences compared to the controls in regard to the mRNA levels of the following genes: IL1B and IL1A (COVID-19 with cardiovascular involvement vs. controls, ANOVA Tukey post hoc test, p adjusted <0.05), as well as IL1B, NR1H3, IL1RN, and ERAP1 (COVID-19 without cardiovascular involvement vs. controls, ANOVA Tukey post hoc test, p adjusted <0.05) (Supplementary Figure S8). This evidence concerns the gene ERAP1 and COVID-19.