Accordingly, damage to intercellular junctions was shown to precede pepsin-induced erosive lesions in the rabbit esophageal epithelium by Tobey et al. [49], and cleavage of the major protein constituent of adherens junctions, E-cadherin, is observed in GERD and LPR biopsies [45,78,79,80]. The gene discussed is CDH1; the disease is gastroesophageal reflux disease.