VEGFA and Sepsis: In a first study exploring SIRT6 role in HUVECs, LPS was administered to simulate endothelial inflammation in a context of sepsis: SIRT6 silencing was accompanied by the increased expression of pro-inflammatory cytokines, extracellular matrix remodeling enzymes, the adhesion molecule ICAM-1, and proangiogenic growth factors VEGF and FGF-2 [7].