Moreover, SIRT6 overexpression decreased the levels of multiple genes involved in vascular inflammation and atherosclerosis, such as VCAM-1, ICAM-1, and platelet selectin (P-selectin), leading to the reduced infiltration of macrophages and foam cells [28], and inhibited TNFα-induced inflammation in HUVECs regulating the Nrf2 signalling pathway [8,27]. Here, TNF is linked to atherosclerosis.