APEX1 and breast cancer: Moreover, Amuran et al., after uEV isolation using the Norgen kit, combined EV-derived miR-139-5p, miR-136-3p, miR-19b1-5p, and miR-210-3p with the urinary proteins Ape1/Ref1, BLCA4, CRK, and VIM into a panel able to discriminate BC (especially low-risk) patients from HC with 93.3% sensitivity and 95.5% specificity and 80.0% sensitivity and 86.4% specificity, respectively [77].