Therefore, we hypothesize that the overexpression of NAGS, CPS1, and citrin promotes the proliferation of glioblastoma, glioblastoma multiforme, stomach adenocarcinoma, and stomach and esophagus carcinoma cells through the increased biosynthesis of pyrimidine nucleotides and/or dysregulated malate-aspartate shuttle. Here, CPS1 is linked to glioblastoma.