BCL2 and B-cell chronic lymphocytic leukemia: MiRNAs whose alteration leads to cancer development are commonly called oncomirs; they were first described in cases of chronic lymphocytic leukemia (CLL) where the expression of two miRNAs (miR-15a and miR-16-1) was upregulated, affecting the expression of antiapoptotic B-cell lymphoma 2 (Bcl2) protein [14].