PGF and placental abruption: Dramatically increasing the sFlt1/PlGF ratio can lead to pathological changes that are typical to pre-eclampsia: placental abruption [22], placental hypoxia [23], ischemic placental disease [24], placental vascular lesions [25], oxidative stress [26,27], endoplasmic reticulum stress [23,28], and maternal endothelial sensitization [23] (Figure 1).