PGF and type 1 diabetes mellitus: Pre-eclamptic women with pregestational type 1 or type 2 diabetes mellitus (T1DM or T2DM) had higher levels of sFlt-1, lower levels of PlGF, and higher sFlt1/PlGF ratios than pre-eclamptic women without pre-eclampsia, according to earlier research [114,115,116].