New risk factors for an increased sFlt1/PlGF ratio include lower blood IgG, albumin, C4 levels, and larger sFLC, HS-CRP, B2-M, TPR, phthalate, COVID-19, AFLP, peripartum cardiomyopathy, and aberrant myocardial performance and OSI. This evidence concerns the gene C4A and peripartum cardiomyopathy.