Additionally, studies have shown that in renal myofibroblasts TGF-β1 stimulates p53 phosphorylation which will activate SMAD (small worms and mothers against decapentaplegic) canonical signaling with resultant myofibroblast activation/differentiation, ECM deposition, and finally renal fibrosis [265,266,267]. Here, TGFB1 is linked to renal fibrosis.