Multiple clinical manifestations contribute to the phenotypic heterogeneity of PRPH2-associated retinopathy, including pattern dystrophy (PD; OMIM 169150) [6]; vitelliform macular dystrophy (VMD; OMIM 608161) [7]; retinitis pigmentosa (RP; OMIM 608133) [8]; cone-rod dystrophy (CRD); and central areolar choroidal dystrophy (CACD; OMIM 613105) [9]. The gene discussed is PRPH2; the disease is central areolar choroidal dystrophy.