NFE2L2 and congestive heart failure: Moreover, a classical pharmacological inducer of NRF2, CDDO-Me, which modifies the Cys151 of KEAP1 resulting in NRF2 stabilisation [125], significantly improved the CHF stroke volume and cardiac output with the simultaneous restoration of NRF2 protein expression and reduced cardiac oxidative stress measured by confocal microscopy [124].