Core enrichment subset in the cholesterol homeostasis pathway also includes genes coding for proteins involved in lipid metabolic disorders, some of which link lipoprotein metabolism with cholesterol homeostasis (Lpl, Ldlr) and the cholesterol biosynthetic enzymes (Dhcr7, Nsdhl, and Ebp) (depicted as heat map in Figure 7C) [51,52]. Here, LDLR is linked to Disorder of lipid metabolism.