Using paired analysis, we show that IgG responses to the virion proteins ORF38 (tegument) and K8.1, as well as latency-associated nuclear antigen (LANA encoded by ORF73 and released during host cell destruction), were significantly elevated by the third day as acute malaria episode resolved during the 3-day course of anti-malarial treatment. This evidence concerns the gene KRT81 and malaria.