STAT3 and colitis: It has been reported that R could inhibit MC inflammatory functions by reducing the expression of the high-affinity receptor for immunoglobulin (Ig)E, FcεRI, on human Laboratory of Allergic Diseases (LAD)2 MC line [21], preventing an increase in MC numbers in allergic enteritis, colitis [22], passive cutaneous anaphylaxis [23], and signal transducer and activator of transcription 3 (Stat3) activation [24].