Finally, it’s possible to overexpress SCAI without fusion, which we, however, don’t consider an optimal strategy because SCAI is involved in the epi-thelial-mesenchymal transition of proximal tubular epithelial cells and in some cancers (gastric, prostate, colorectal) high SCAI expression correlated with poor survival of patients [13]. The gene discussed is SCAI; the disease is cancer.