A large number of genes involved in carbon metabolism were significantly down-regulated in Ogura CMS, including 10 arabinogalactan protein genes, five fasciclin-like arabinogalactan protein genes, two beta-1,3-galactosyltransferase genes, one formate-tetrahydrofolate ligase gene, one metallenetetrahydrolase reductase gene, one UDP-arabinose 4-epimerase 3 gene, one ADP-ribosylation factor gene, and one eglucan endo-1,3-beta-glucosidase gene. The gene discussed is B3GALT1; the disease is congenital myasthenic syndrome.