Indeed, in the present study, we found that hMMP-2 transgenic (TG) mice with lung fibrosis show significantly lower protein levels and mRNA expression of collagen and lower relative mRNA expression of fibronectin and α-SMC in the lungs than their wild-type (WT) counterparts, suggesting a possible direct effect of hMMP-2 on matrix protein production. The gene discussed is FN1; the disease is pulmonary fibrosis.