We found a trend for elevated P-selectin levels in patients admitted to the ICU; (ii) cfDNA and CitH3 NETs correlated with lymphopenia and analytical parameters (CRP, LDH and DD) related to COVID-19 progression; (iii) A multistep model was developed to estimate the different clinical trajectories of patients who visited the ED with COVID-19 and had CitH3, cfDNA and P-selectin measured. Here, SELP is linked to COVID-19.