ADORA2A and hyperinsulinemic hypoglycemia, familial, 4: The INOH-path enrichment analysis revealed that the elevated A2AR expression in CCGA males compared with TCGA astrocytoma was related with upregulation of the pyruvate kinase deficiency, glutaminolysis, hyperphenylalanimia, and sugar metabolism pathways in this group, which, if A2AR was associated with it, led to a poor prognosis (CGGA men) compared to the TCGA astrocytoma group.