Another candidate involved in the pathogenesis of PBC, according to Selmi et al., is the ubiquitous bacterium Novosphingobium aromaticivoran, which causes a potential break in tolerance to the self E2 component of the mitochondrial pyruvate dehydrogenase complex (PDC-E2) through two independent mechanisms [46]. The gene discussed is DLAT; the disease is primary biliary cholangitis.