This correlation has been shown in a mouse model with gastritis and gastric cancer, where isthmus stem cells exhibit a proliferative tendency with the expansion of CXCL12+ endothelial cells and CXCR4+ ILC2s, in which the inflammatory CXCL12/CXCR4 chemokines has been thought as an important signaling molecule in gastritis and gastric cancer [130]. The gene discussed is CXCL12; the disease is gastritis.