EGFR is a family of proteins that the human epidermal growth factor (HER) belongs, which activation determines the activation of multiple signaling pathways, including mitogen-activated protein kinase/Extracellular signal-regulated kinase 1⁄2 (MAPK/ERK) and phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/AKT/mTOR), and plays a role in maturation, proliferation, inhibition of apoptosis even at the tumor level, leading to tumor growth. The gene discussed is EGF; the disease is neoplasm.