VEGF has been shown to improve the cognitive decline in Tg2576 AD mouse model by inducing ADAM10 expression and decreasing BACE1 production [217], thus suggesting the existence of a loop between APP cleavage fragments functions, PKC/nELAV/VEGF pathway and the potential protective functions of non-amyloidogenic sAPPα. This evidence concerns the gene BACE1 and Alzheimer disease.