The chromatin immunoprecipitation with antibodies against repressor element-1 (RE1)-silencing transcription factor (REST) inactivated transcription, one of the EHMT2 interacting protein, revealed the repressed downstream genes SNAP25 and L1CAM. SNAP25 is a major component of SNARE complex involved in synaptic function; thereby, these changes may contribute to the synaptic dysfunction that occurs in PD brain [106]. This evidence concerns the gene REST and Parkinson disease.