In view of the fact that BMP7 is a multifunctional growth factor belonging to the TGF-β superfamily with anti-inflammatory and antifibrotic properties [86], its involvement in the development of endometriosis may coincide with the EMT and be associated with BMP7 signaling dysregulation that is dependent on the SMAD4 signal loop. This evidence concerns the gene SMAD4 and endometriosis.