BCHE and Alzheimer disease: The drugs approved by the US Food and Drug Administration (FDA) for the treatment of AD include the cholinesterase inhibitors donepezil, galantamine and rivastigmine; the N-methyl-D-aspartate (NMDA) receptor antagonist memantine; a combination of memantine and donepezil; the monoclonal antibodies targeting Aβ aducanumab and lecanemab [14,15,16,17,18].