A double-blind placebo-controlled trial [40] involving 80 overweight participants with suboptimal fasting plasma glucose, which were randomized to be treated with curcumin 800 mg/day or a placebo for 8 weeks, demonstrated that the supplementation of a phytosomal preparation of curcumin containing phosphatidylserine and piperine for 56 days of treatment, reduced plasma insulin (FPI), HOMA index, TG, LDL, hepatic transaminases, γ-GT, cortisol level, and a reduction of waist circumference, blood pressure and liver steatosis index as well. Here, INS is linked to fatty liver disease.