The daily co-administration of 500 mg of curcuminoids with 5 mg of piperine for 12 weeks, in 70 patients with NAFLD [38], was showed to cause a reduced hematocrit, erythrocyte sedimentation rate, serum concentration of alanine aminotransferase, total cholesterol, LDL, iron and hemoglobin, iron-binding capacity and albumin levels. The gene discussed is GPT; the disease is metabolic dysfunction-associated steatotic liver disease.