In a randomized-controlled trial conducted in T2D adult patients aged 18–65 years [12], the daily co-administration of 500 mg/day of curcuminoids with 5 mg/day of piperine for three months versus placebo caused a reduction of serum glucose, C-peptide and HbA1c, alanine aminotransferase and aspartate aminotransferase level. This evidence concerns the gene GPT and type 2 diabetes mellitus.