IFNG and neoplasm: Interestingly, it was discovered that CD@MSN-mediated PTT could achieve immune-mediated prevention of tumor metastasis by promoting the proliferation and activation of NKs and macrophages while upregulating the production of cytokines such as IFN-γ and granzyme B. This study offered an unconventional method of producing biodegradable mesoporous silica and gave novel insights into the anticancer immunity associated with biodegradable nanoparticles [62].