Histopathology of AD has been well studied and is represented by neuronal loss in the cerebral cortex, the hippocampus, and the amygdala; it is also associated with the presence of senile plaques containing β-amyloid peptide (Aβ) and neurofibrillary tangles (NFTs), which are composed of straight or helical filaments of abnormally hyperphosphorylated tau [94]. This evidence concerns the gene MAPT and Alzheimer disease.