In another study, Lehmann et al. found that RelA/p65 nuclear translocation as well as RelA/p65 DNA binding activity could be markedly diminished using HDAC inhibitors, which could thus be used to suppress NF-kB activity and lead to enhanced apoptosis and chemosensitization of pancreatic cancers [22]. The gene discussed is RELA; the disease is familial pancreatic carcinoma.