The H. pylori strain ATCC 49503-infected 2-D gastric cancer cells showed rapid growth and the highest expression of HDGF, NF-kB, and IL8 [12], while both the moderately-toxic strain HpHtrA171/nonL and non-CagL Y58/E59 H. pylori-infected organoids and the non-cytotoxic strain H. pylori CagLm Y58D/59K-infected organoids showed the lowest invasion activities and growth of the organoids [18,22]. This evidence concerns the gene HDGF and gastric cancer.