We found that metastatic melanoma cell lines express significantly higher levels of many genes, including BCL-2, IGF-1, EGFR, FGFR2, MMP1, MMP2, MMP3, RHOU, TNF, IL1B, FLT-1 and MAGEC1, when compared to the PM cell line, although some of them were oppositely expressed between MNT-1 and VMM1. The gene discussed is IGF1; the disease is metastatic melanoma.