However, the multi-level analysis highlighted a short list of candidate genes (EGFR, MMP2, IL1B, MAGEC1) and miRNAs (miR-100, miR-125b, miR-129, several let-7 family members) that may have a causative role in the malignant progression of melanoma, and which could represent promising targets for future investigation. This evidence concerns the gene MMP2 and melanoma.