MMP2 and melanoma: As shown in Figure 6A, EGFR, MMP2, IL1B and MAGEC1 gene expression levels showed consistent up-regulation (in the sense of the immunohistochemical expression of the homologous genes), with statistically significant increases of more than 20-fold (p < 0.0001) in metastatic sites (n = 10 each) compared to primary melanoma (n = 10).