Moreover, IL1B and its family member IL-18 were demonstrated to promote invasion and angiogenesis through the activation of NF-κB, which triggers the secretion of VEGF from tumor cells, induces their proliferation and migration, prevents apoptosis, and may also induce PD1-dependent immunosuppression of natural killer (NK) cells [22]. Here, NFKB1 is linked to neoplasm.