In a small cohort of patients with thrombotic thrombocytopenic purpura, however, IL-8 and TNF-alpha levels, although removed by each TPE session, rebounded the day after separation [31], which indicates that the mechanism behind the associated cytokine overproduction is independent of the acute TPE intervention. The gene discussed is CXCL8; the disease is thrombotic thrombocytopenic purpura.