FNDC5 and Stroke: As another destructive form of stroke, Subarachnoid hemorrhage is relieved through the administration of exogenous Irisin, which provides neuroprotective effects including maintaining mitochondrial morphology and promoting mitochondrial biogenesis [29] Thus, the exercise-induced hormone Irisin plays vital neuroprotective roles against stroke-related pathophysiology, including oxidative stress, inflammation, and apoptosis.