Since we found that hCad-11-Fc significantly increased the production of inflammatory cytokine IL-6 in fibroblasts, and IL-6 plays an important role in cardiac hypertrophy, it is reasonable to hypothesize that the IL-6 secreted by fibroblasts upon hCad-11-Fc stimulation directly modulates cardiac hypertrophy through paracrine mechanism. Here, IL6 is linked to cardiac hypertrophy.