A large number of studies have proven that DAPK1 plays an Important role in mediating the pathological process of acute and chronic neurological disorders, such as Alzheimer’s disease (AD) [9,17,18,19,20], Parkinson’s disease (PD) [21,22], Huntington’s disease (HD) [23], traumatic brain injury (TBI) [24,25], stroke [15,26,27,28], and epilepsy [10,11]. The gene discussed is DAPK1; the disease is early-onset autosomal dominant Alzheimer disease.