DAPK1 and ischemia: In addition, DAPK1 modulates brain damage via the NMDA receptor or alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor by ischemia and inhibition of DAPK1 activity, which contributes to neuroprotective effects in a mouse model of ischemia [15,28,36,37].