-Neoplastic Schwann cells produce pro-inflammatory cytokines that may act in an autocrine manner, stimulating cellular proliferation-The increased expression of VEGF suggested that this factor might induce neoplastic growth via angiogenesis.-Inflammation might promote angiogenesis and consequently contribute to tumor progression-VEGF and pro-inflammatory cytokines could be potential therapeutic targets in VS. The gene discussed is VEGFA; the disease is neoplasm.