While 14 days of musclin infusion did not significantly reduce myocardial infarct size in sedentary Ostn-KO mice (Figure 7B,C), 28 days of treatment reduced infarct size following IR (48.57 ± 2.14 vs. 59.69 ± 3.30%, n = 7–8 and p = 0.013 in Figure 7B,C). This evidence concerns the gene OSTN and myocardial infarction.