CHRNA7 and cancer: Moreover, the protein level of α7 nAChR is significantly downregulated in the sciatic nerve, dorsal root ganglion (DRG) and spinal cord in animal pain models of different etiology, providing a cellular and molecular basis for the known alleviation of chronic pain, including neuropathic pain, inflammatory pain and cancer-induced bone pain owing to activation or positive modulation of α7 nAChR (reviewed in [178]).