Through the regulation of the cholinergic anti-inflammatory pathway (reviewed in [177,190]), the CHRFAM7A gene expression level is linked to the severity of inflammatory-related pathologies, such as sepsis, osteoarthritis [191,192], cerebral ischemia/reperfusion injury, hypertrophic scars, COVID-19, inflammatory bowel disease [193], renal fibrosis [194] and pain, including neuropathic pain after spinal cord injury [195] and inflammatory pain due to osteoarthritis modeling [192]. This evidence concerns the gene CHRFAM7A and osteoarthritis.