AFP and neoplasm: On the other hand, the meta-analysis results showed that, apart from AFP (OR 4.63; 95% CI, 1.13–19.09; p = 0.03) and tumor number (OR 1.89; 95% CI, 1.08–3.33; p = 0.003) in PD-1 and age (OR 1.95, 95% CI:1.24, 3.06, p = 0.004), tumor size (OR 2.08; 95% CI, 1.46–2.98, p < 0.0001) in PDL-1, the correlations between PD-1/PDL-1 expression and clinicopathological features were not statistically significant (p > 0.05).