SOST and hyperostosis corticalis generalisata: Sclerostin (SOST) is a glycoprotein secreted by osteocytes in response to mechanical stress on the bone and has been shown to play a role in bone formation and remodelling, with the loss of SOST resulting in Van Buchem disease, associated with endosteal hyperostosis of the mandible, skull, ribs and clavicles, as well as diaphysis of the long bones [77,78].