This review will primarily focus on the pathophysiological effects of various interleukins including the IL-1 family (IL-1, IL-18, IL-33, IL-37), IL-2, IL-4, the IL-6 family (IL-6 and IL-11), IL-8, IL-10, IL-17 on primary cells of heart disease-CMs, FBs, ECs, and immune cells. This evidence concerns the gene IL17A and heart disorder.