In contrast, IL-2 plus IL-2 monoclonal antibody clone JES6-1 complexes (IL2/JES6-1) administration increased Tregs, suppressed leukocyte infiltration, including decreasing CD45(+) cells, macrophages, CD8(+) T cells, and effector memory CD8(+) in mice hearts before TAC-induced CHF, then attenuated the development of LV hypertrophy and dysfunction [106]. The gene discussed is CD8A; the disease is congestive heart failure.