In this review, the pathophysiological effects of interleukins including the IL-1 family (IL-1, IL-18, IL-33, and IL-37), IL-2, IL-4, the IL-6 family (IL-6 and IL-11), IL-8, IL-10, and IL-17 on primary cell types of heart disease is elucidated (Figure 1). The gene discussed is IL18; the disease is heart disorder.