Despite several emerging information have described the potential biological role of lncRNAs in diverse diseases, how lncRNAs could allow discrimination between the two major asthma endotypes remain unknown, and due to the reported links to inflammation, obesity, and lung diseases, we selected the following four lncRNAs HOTAIRM1 [16], GAS5 [17], MZF1-AS1 [18] and OIP5-AS1 [19] as potential biomarkers implicated in asthma. Here, GAS5 is linked to obesity due to melanocortin 4 receptor deficiency.