In a Dutch study including 221 women, among whom 167 had CIN1 or normal histology, 54 had CIN2/3 and 44 had cervical cancer; higher methylation levels of CADM1 and MAL were found in CIN2/3 lesions and cervical cancer samples in comparison to ≤CIN1 (5.3- and 6.2-fold increased methylation level of CADM1 and MAL; p < 0.0005). The gene discussed is MAL; the disease is cervical carcinoma.