In addition, we have previously shown that SELENOM-KD in human glioblastoma cells (A-172 line) leads to increased expression of a number of key pro-apoptotic genes, two selenoproteins SELENOT and SELENOK, and two glutathione peroxidases GPX1 and 2, thioredoxin reductase 3 (TXNRD3), as well as the transcription factor ATF-4, which may indicate activation of the PERK signaling pathway UPR [13]. The gene discussed is TXNRD3; the disease is glioblastoma.